Lab Mission

Our laboratory studies the interaction between fluid flow and biology, by integrating fluid dynamic engineering, cellular and molecular biology. Body fluids or biofluids, such as blood, lymph, and cerebrospinal fluid continuously interact with cells in the body eliciting biochemical and physical responses. Our research seeks to elucidate the fluid flow characteristics and fluid flow-dependent biomolecular pathways relevant in medicine.

Research

Cardiovascular stents, fluid flow and endothelial cell phenotype

Cardiovascular stents, fluid flow and endothelial cell phenotype

Our research explores how blood flow perturbations caused by the stent design contribute to in-stent restenosis and thrombosis, studying the impact of the fluid forces on blood components and endothelial cells.

Cerebral aneurysm formation, fluid flow and vascular phenotype

Cerebral aneurysm formation, fluid flow and vascular phenotype

In collaboration with clinicians and computation fluid dynamicists, our laboratory explores how blood flow in the cerebral vasculature may play a role in the initiation and progression of cerebral aneurysms.

The role of lymphatic fluid flow in development, immunity, cancer metastasis and lymphedema

The role of lymphatic fluid flow in development, immunity, cancer metastasis and lymphedema

In collaboration with a team of cardiologists and vascular biologists, we have demonstrated that fluid flow serves as a physical stimulus inducing expression of genes required for lymphatic valve development.

Sperm Motility

Sperm Motility

In collaboration with Dr. Pablo E. Visconti from the UMass Department of Veterinary & Animal Sciences we are studying the effects of different chemoattractant and chemorepulsive signals on sperm motility and its relation to fertility.

Fish Mechanotransduction

Fish Mechanotransduction

Bone mechanotransduction is critical for normal growth and bone health. We are studying the effects of exercise on mechanotransduction and bone growth.

Get in Touch

ADDRESS

University of Massachusetts
N560 Life Sciences Laboratory
240 Thatcher Way
Amherst
MA 01003-9364

Email

juanjimenez { at ] umass DOT edu

Contact Us